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Exploring PRP and Stem Cell Therapy for Cervical and Lumbar Spine Disc Degeneration


Degenerative disc disease (DDD) affecting the cervical and lumbar spine is

a common cause of chronic pain and disability. Traditional treatments often focus on

managing symptoms rather than addressing the underlying degeneration. However,

emerging regenerative medicine techniques such as Platelet-Rich Plasma (PRP) and

Stem Cell therapy offer promising alternatives by targeting tissue repair and

regeneration. In this article, we delve into the potential of PRP and Stem Cell therapy in

managing disc degenerations.

Understanding Disc Degeneration:

Disc degeneration involves the breakdown of the

intervertebral discs, leading to decreased disc height, loss of hydration, and structural

changes. This process contributes to pain, stiffness, and reduced mobility in affected

individuals. Conventional treatments like medication, physical therapy, and surgery may

provide symptomatic relief but often fail to address the underlying degeneration.

Platelet-Rich Plasma (PRP): PRP therapy involves the injection of concentrated

platelets derived from the patient's blood into the affected area. Platelets contain growth

factors and cytokines that promote tissue repair and regeneration. Several studies have

explored the efficacy of PRP in treating disc degeneration.

A study by Tuakli-Wosornu et al. (2016) demonstrated that intradiscal PRP injections

led to significant improvements in pain and function scores for patients with

symptomatic disc degeneration. Another study by Levi et al. (2019) reported

improvements in pain and disability scores following PRP injections in patients with

lumbar disc degeneration.

Stem Cell Therapy:

Stem cell therapy involves the transplantation of stem cells, either

from the patient's own body or from a donor, into the damaged tissue to facilitate repair

and regeneration. Mesenchymal stem cells (MSCs) are of particular interest due to their

ability to differentiate into various cell types and modulate the immune response.

Research into stem cell therapy for disc degeneration is ongoing, with promising results.

A study by Orozco et al. (2011) found that intradiscal injection of autologous MSCs

resulted in improvements in pain and disability scores for patients with chronic disc

degeneration. Similarly, a study by Centeno et al. (2017) reported improvements in pain

and function following intradiscal injection of bone marrow-derived stem cells.

At DB2 Regeneration, we go beyond merely offering therapies. We seamlessly integrate

them into our comprehensive 360-degree approach, leveraging cutting-edge, evidence-

based rehabilitation strategies for enhancing strength, stability, and proprioception. Our

services extend to include chiropractic adjustments to optimize joint motion, along with

non-invasive spinal decompression utilizing state-of-the-art computerized technology,

aimed at alleviating pain and restoring mobility. This is the DB2 difference – a fusion of

services dedicated to enhancing your quality of life.


Platelet-Rich Plasma (PRP) and Stem Cell therapy represent innovative

approaches to addressing cervical and lumbar spine disc degenerations. While further

research is always valuable, we know now these therapies offer long-term efficacy and

safety, based on current evidence. If you or a family member have suffered from neck

pain or low back pain associated with degenerative disc disease, DB2 invites you

schedule an appointment. Check out our integrated non-surgical approach to disc

disease, isn’t it time you or your loved one to find real solutions to pain without

controlled substances? Call 636 265-2822 or go to


1. Tuakli-Wosornu YA, Terry A, Boachie-Adjei K, et al. Lumbar Intradiskal Platelet-

Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized

Controlled Study. PM&R. 2016;8(1):1-10.

2. Levi D, Horn S, Tyszko S, Levin J, Hecht-Leavitt C, Walko E. Intradiscal platelet-

rich plasma injection for chronic discogenic low back pain: preliminary results

from a prospective trial. Pain Med. 2019;20(11):2241-2247.

3. Orozco L, Soler R, Morera C, Alberca M, Sánchez A, García-Sancho J.

Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot

study. Transplantation. 2011;92(7):822-828.

4. Centeno CJ, Markle J, Dodson E, et al. Treatment of lumbar degenerative disc

disease-associated radicular pain with culture-expanded autologous

mesenchymal stem cells: a pilot study on safety and efficacy. J Transl Med.


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